University of California, Santa Cruz

Department of Chemistry and Biochemistry


The Stone Research Group combines the use of biochemical techniques with newly emerging single-molecule biophysical methods to probe enzyme structure and dynamics of protein-nucleic acid complexes. Our current area of focus is the structure and function of the telomerase ribonucleoprotein, an RNA-dependent DNA polymerase that maintains genomic stability by synthesizing repetitive DNA sequences at chromosome termini.  These short DNA repeats form the foundation of specialized chromatin structures, called telomeres, that prevent deleterious chromosome fusion events by differentiating chromosome ends from sites of DNA damage. Click here to learn more.

Lab News

  • Congratulations to Salina and Ben who both successfully defended their dissertation research this month! The first two PhD's from the Stone Research Group....way to go!

  • Joe's paper was published in Nature Communciations! 

  • Congratulations to Linnea on recieving the UCSC MCDB NIH training grant!

  • The Stone Research Group welcomes its newest member, Linnea Jansson from the Molecular, Cell, and Developmental Biology Department. 

  • Undergraduate Hanae Armitage recently published an article on the lab's telomere DNA work.

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