The Stone Research Group combines the use of biochemical techniques with newly emerging single-molecule biophysical methods to probe enzyme structure and dynamics of protein-nucleic acid complexes. Our current area of focus is the structure and function of the telomerase ribonucleoprotein, an RNA-dependent DNA polymerase that maintains genomic stability by synthesizing repetitive DNA sequences at chromosome termini. These short DNA repeats form the foundation of specialized chromatin structures, called telomeres, that prevent deleterious chromosome fusion events by differentiating chromosome ends from sites of DNA damage.
Click on one of the images below to learn more about the projects in the lab.
|Telomerase FRET||Force-FRET G-Quadruplex||Telomerase Structure Probing|