Telomere DNA G-Quadruplex Structure

Telomeres are specialized nucleoprotein structures that protect the natural ends of linear eukaryotic chromosomes from aberrant processing and recognition by DNA damage repair machinery. Telomere DNA is comprised of repetitive DNA sequences (TTAGGG  in humans) that confer unique structural properties to these essential regions of the genome. Our lab is interested in characterizing diverse telomere DNA structures, such as G-quadruplexes and telomeric displacement loops (D-loops), using single molecule force and fluorescence spectroscopy. The aim of this research is to understand how the unique physical properties of telomeres impact critical telomere DNA transactions such as replication and recombination.